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Even though some patients have mutations in TARDBP , the gene that codes for TDP-43 protein, not all TDP-43 pathologies are associated with the mutation 10 , and not all protein accumulations occur in the cytoplasm, some are detected in the nucleus 11, 12

This process generates ATP, providing a rapid increase in available cellular energy

By integrating our metabolic model with the expression dynamics of genes involved in cell cycle progression and DNA repair, thus, our systematic framework can be extended to provide more comprehensive and robust solutions for both phenotype and production instability in CHO cells during the LTC

1094 Uncoupling proteins offer new ways to bolster the cellular defense against oxidative stress