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In retina and optic nerve, TNF is rapidly release from glial cells (i.e., microglia, Mller cells) as a response to cell-stress inducing factors, like increased intraocular pressure ( 2+ permeability of AMPA receptor (AMPAR) and accumulation of Ca 2+ in cytosol, mitochondrial damage and ROS production (Tezel, 2008)

Cellular senescence: Putting the paradoxes in perspective

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The Tricarboxylic Acid Cycle While the TCA cycle is commonly thought of as an NADH and FADH 2 producing pathway, it also generates NADPH