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Br J Cancer 1997

Visit MedWatch or call 1-800-FDA-1088.

Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes

chelation of the copper site by the thiol group, interference with the cellular transfer of tyrosinase to premelanosomes, which is the site of melanin synthesis and indirect inhibition of tyrosinase via its antioxidant effect as the free radical scavenging effect of it blocks the induction of tyrosinase activity caused by peroxides