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Although the precise receptor for SHBG has not been identified to our knowledge, SHBG has been reported to bind to G protein-coupled receptor 6A [194], which is proposed to regulate energy metabolism in insulin-sensitive tissues as well as stimulate the release of glucagon-like peptide-1 and adiponectin, key regulators of glucose homeostasis [195]

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A search of Genbank and EST databases identified two different glutathione peroxidase genes (Figure S6)