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CAN is characterized by reduced heart rate variability and is associated with an increased risk of mortality in people with diabetes

There is insufficient evidence for the use of B12, beyond correction of deficiency, in cognitive impairment, depression and fatigue

DMT1 gene mutations are associated with severe microcytic anemia and iron overload [35]

Interestingly, we observed heterogeneous expression of classical zonated hepatocyte markers, with a fraction of hepatocytes expressing periportal markers ( SAA1 , SAA2 and APOA1 ) and others expressing pericentral markers ( CYP2E1 ) (Fig