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GHRH receptor signaling Tesamorelin activates a Gs-coupled receptor on pituitary somatotrophs, increasing adenylate cyclase, cyclic AMP, protein kinase A signaling, GH synthesis, and GH release

PHD2 is present in most tissues, whereas PHD1 is mainly in testes but also in brain, kidney, heart, and liver, and PHD3 showed highest expression in the heart