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[link] Crowell PD, Goldstein AS, "Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer", Mol Cell Oncol 4 (2): (2017)

Crotonylation of PKM2 at the K305 site can promote the formation of dimers after nuclear translocation and promote the expression of glycolysis-related proteins GLUT1 and LDHA, increase glycolysis intermediates such as pyruvate and fructose-1,6-bisphosphate, and induce upregulation of PCNA and OPN, and downregulation of CNN1, -SMA, and Transgelin [99]