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The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]

However, this study used only hemolytic assay in vitro to measure toxicity and lacks toxicological evaluation in vivo and thus alarming their use in clinical practice

The peptide consists of four amino acids in the sequence Ala-Glu-Asp-Gly, forming a simple yet biologically active compound with potential effects on cellular aging processes

The animal science is genuinely interesting