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For example, a mitoprotection bundle for high-risk surgery might include: a) a sulforaphane-based supplement a day before surgery (to activate Nrf2 antioxidant responses), b) remote ischemic preconditioning during anesthesia induction (209), c) low-dose IL-1ra (anakinra) at start of reperfusion, d) postoperative Dexmedetomidine infusion, and e) high-protein nutrition with omega-3 fatty acids to support recovery

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Later complications include anemia and neuropathy

Common mechanisms of ferroptosis including iron overload, lipid peroxidation, GPX4 inhibition, and system Xc inhibition in obesity, which lead to decrease of GSH, increased ROS, and even ferroptosis