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This is the first demonstration that long-term exposure to a TGF antagonist in mice does not manifest any major adverse effects

10.1016/j.cell.2024.07.012 4 AvrutskyM

Notably, the selective uptake of cystine (an oxidized dimer of cysteine), rather than methionine, as a precursor for cysteine and subsequently GSH biosynthesis imposes a further metabolic constraint: the reduction of cystine to cysteine requires NADPH, the supply of which becomes critical for GSH biosynthesis (see Supplementary Fig

13,14 The full value of bonding a filled-resin type of material to create a reinforced smooth surface sealant, such as shown here, would make for a worthy in vitro study in an artificial caries model