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Common causes of knee pain include: Osteoarthritis : The most frequent culprit, where cartilage gradually breaks down over time Meniscus tears : Damage to the shock-absorbing cartilage in your knee Tendinosis : Chronic degeneration of tendons around the knee Ligament injuries : Sprains or tears in the supportive structures Inflammatory conditions : Including rheumatoid arthritis and lupus Referred pain : Sometimes hip problems can cause knee discomfort Traditional treatments typically involve anti-inflammatory medications, physical therapy, steroid injections, or in severe cases, surgery

An informative example worth considering is the HOPE-2 trial (49)

They can help decide if more shots are right for you and what risks they carry

doi:10.1515/znc-1994-9-1023