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[PMC free article: PMC1683844] [PubMed: 2339702] 250

Oral therapy There is no oral agent that cures Peyronies disease and most of the commonly used treatments that patients source from, or investigate on the internet, have had no efficacy in proper clinical trials

This rapid accumulation of lactic acid and the resulting drop in cellular pH is a primary driver of post-exertional malaise (PEM), the hallmark symptom of ME/CFS and Long COVID

Patients may look to supplements to manage ME/CFS for many reasons, for example, because of lack of medication options offered by clinicians, preference for complementary and integrative methods, or sensitivity to pharmaceuticals