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In COPD, oxidative stress-induced ROS not only affects macrophage polarization but may also impair mitochondrial function, leading to cellular senescence and phagocytic dysfunction

de Carvalho, C

R.FerrariM

For example, energy expenditure and energy intake are dynamically interrelated by physiological counteracting mechanisms (e.g., adaptive thermogenesis corresponding to a reduced energy expenditure if energy intake is decreased [65]) that are nearly impossible to look at in an isolated fashion [66]