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doi: 10.1016/j.fsi.2021.02.012 197 MorettiC

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[00295] Provided are methods of modifying melanin distribution by modulating prostaglandin F2 alpha (PGF2 alpha) in a cell, comprising contacting said cell with a composition comprising from about 0.01%) to about 2% substituted benzaldehyde, about 0.01% to about 5.0% each of Retinol, Niacinamide, Tetrahexyldecyl Ascorbate, Glycyrrhiza Glabra (Licorice) Root Extract, Hexyl Resorcinol, ethyl linoleate, and a pharmaceutically or cosmetically acceptable carrier

134 , 135 Moreover, the DPI co-loaded with baicalein/ambroxol hydrochloride demonstrated antifibrotic, anti-inflammatory, and antioxidant effects of pirfenidone due to its pulmonary targeting, rapid onset of action and high pulmonary bioavailability