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Other pathways implicated, explaining the development of vitiligo, include autophagy and ferroptosis, where oxidative stress impacts the cells ability to clear damaged components, eventually leading to cell death and depigmentation 17,46

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Cardiovasc Res (2021) 117(6):145088

163 In addition, Tfh cell production and function are dependent on Notch signaling, Notch receptors 1 and 2 are required for Tfh cell production, and Notch signaling enhances the production of type 2 cytokines in Tfh cells