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Aging Cell 9 , 4053 (2010)

Misery L et al

At higher inhibitor concentrations, the curves were not hyperbolic, but became polynomial, suggesting that more than one binding site of OPZ is involved in the presence of reacted and unreacted enzymes species in mixture

the four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, gut wall enzymes, bacterial enzymes, and hepatic enzymes