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Image analysis Maximum intensity projection images were analyzed with ImageJ (NIH)

[59] [29] Darrell Wilkinson, a British dermatologist, gave an accurate description of the clinical entity in the 1950s

First, a rapid decline in serum urate levels may disrupt pre-existing crystaldissolution equilibria, leading to structural rearrangement of deposited MSU crystals, exposure of previously concealed crystal surfaces, or mobilization of microcrystalline particles

Individual responses to timing vary considerably, and there is no clinical evidence that nighttime administration reduces gastrointestinal side effects compared to other times of day