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Also, a newer treatment works by blocking male hormones in the skin

Butler IJ, O'Flynn ME, Seifert WE Jr, Howell RR

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Proc Natl Acad Sci USA 94: 1242512430 Zhou Y, Nathans J (2014) Gpr124 controls CNS angiogenesis and bloodbrain barrier integrity by promoting ligandspecific canonical wnt signaling