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Step-2 (S)-4-nitrophenyl 2,6-bis(tert-butoxycarbonylamino)hexanoate (512.0 mg, 1.095 mmol) in solution in dry DMF (5 mL) was added to a solution of Base Structure (460.6 mg, 0.9127 mmol) and LiOH H 2 0 (40.2 mg, 0.958 mmol)

How such antibodies are generated in MDD became evident only two decades later, as will be discussed in one of the next sections