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Consequently, when the FRDA fibroblasts were lifted and allowed to settle, there was decreased spreading, indicating deficient contractility and motility due to this cytoskeletal disarrangement ( In relation to the previously described alterations to mitochondrial function in FRDA, mitochondrial transport along neuronal axons and dendrites is mediated by interactions with cytoskeletal microtubules and neurofilament illustrating a key link between actin, mitochondrial function, and neuronal homeostasis (Sparaco et al., 2009

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Scorletti E, Afolabi PR, Miles EA, et al