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Recent discoveries suggest that NNMT may play important roles in tissue-specific metabolic regulation beyond its established functions in liver and adipose tissue, including potential roles in brain metabolism, immune cell function, and tissue repair processes

Additionally, by increasing satiety rather than simply reducing total energy availability, tesofensine may help maintain adequate protein intake even during caloric restriction, supporting lean mass preservation

With each step-up, the body may need a few days to adapt

Monitoring, Labs, and Outcome Tracking Baseline labs typically include serum B12, methylmalonic acid (MMA), and homocysteine