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NABQI can cause a free radical-mediated peroxidation of membrane lipids, and consequently hepatocellular damage

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How much oxidant is delivered follows a non-linear doseresponse in which modest H 2 O 2 enhances signalling through reversible thiol switches, whereas high local fluxes ignite injury chemistry, including OH generation from H 2 O 2 at iron-rich sites (Goulev et al

I mean, the amount of surface area of your body that's, that's in contact with the ground is important, but it's actually swimming in a natural body of water