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Clinical markers of progression Older age, male sex, higher baseline motor scores and worse baseline cognition have all been linked to worse motor and cognitive outcomes at longitudinal follow-up 141,182,194,195,196 and have been integrated with sleep disorder, presence of depression and various genetic, imaging or CSF biomarkers into clinical predictive scores 182,196

Opposite findings were also reported

Peak plasma concentrations after standard oral doses are in the low nanomolar range (typically 550 nM), far below the micromolar concentrations (150 M) used in most in vitro studies (165, 166)

Despite its curative, diagnostic, or palliative intent, surgery induces a complex inflammatory response that promotes healing and recovery but can also lead to adverse outcomes [4]