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Additional contributing factors include increased expression of insulin-like growth factor 1 (IGF1) receptors, IGF1-binding protein (which protects IGF1 from proteolysis) in Purkinje cells [8], as well as upregulated mRNA expression of GLUT1 and GLUT3 [80]

In the combined effect of antiviral medications and other therapeutic drugs now in use, the use of these natural immunosuppressive drugs as adjuvants to reduce the cytokine storms presents a novel, synergistic strategy for the therapies and effective recovery of COVID-19 patients

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Further research suggests that this oxidative state may be due to androgens enhancing mitochondrial activity, as evidenced by increased oxygen consumption rates and catalase activity, leading to elevated ROS production [26]