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It has been observed that Polo-like kinase 1 (PLK 1) is suppressed in septic rats, leading to reduced expression of IB- and enhanced nuclear translocation of NF-B p65

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Inflammation not only leads to cellular and genomic damage but also alters the tumor microenvironment, enhancing cell proliferation, promoting angiogenesis, and facilitating tissue repairfactors that collectively contribute to tumor growth [92]

Lipid oxidation is largely induced by three different routes: enzymatic oxidation, free-radical-mediated oxidation, and non-radical oxidation (Niki et al., 2005)