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Insights on the kinetics and mechanisms of the peroxyl radical scavenging capacity of caftaric acid: The important role of the acid-base equilibrium

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Within this scope, TVX-induced hepatotoxicity was previously detected and discriminated from its non-toxic analogue LVX in in vitro models, for example in bioprinted 3D primary liver tissue 24 , 3D spheroid co-culture of primary human hepatocytes and Kupffer cells 25 and human liver microphysiological platforms 26,27

The pathogenesis of sarcopenia is complex and multifaceted: the chronic catabolic condition, increased energy expenditure, reduced appetite, side effects of multiple therapies, alterations in circulating levels of hormones, low protein synthesis, and the presence of ascites or portosystemic shunts are all factors contributing to muscle atrophy in cirrhotic patients [23]