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For example, the TfR1 inhibitor Ferstatin II significantly suppresses TfR1 activity in vitro and in vivo , improving cartilage degradation

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These reactions are catalyzed by lysine acetyltransferase (KAT), and the reverse process is regulated by lysine deacetylase (KDAC), while the acetyl group can add to the amino acid at the N-terminus via N-terminal acetyltransferases (NATs) 114,115

For instance, while REW-containing IgG2 is equipped with the capacity to mediate induction of classical complement activation, IgG4 REW remains inert in this regard, which is a differentiator compared to other reported Fc-engineered strategies