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Concurrently, disruptions in intracellular ATP and K + homeostasis elevate reactive oxygen species (ROS) levels, damage mitochondrial DNA (mtDNA), and promote the recruitment of NIMA-related kinase 7 (NEK7) to bind and activate the NLRP3 inflammasome

We would not supersede voluntary alignment for CMS Innovation Center models that are not designed to target a specific disease or condition, such as ACO REACH