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Human studies on hypothalamo pituitary adrenal (HPA) axis ScienceDirect Hypothalamic Pituitary Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System PMC A woman's hormonal system is five times more sensitive to stress than a man's. Studies show that the HPA axis (hypothalamuspituitaryadrenal) in women activates faster and stays active longer. This Genetic Approaches to Hypothalamic Pituitary Adrenal Axis Regulation Neuropsychopharmacology
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