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Physicochemical factors: 1) Drug solubility & dissolution rate 2) Particle Size and Effective Surface Area of the Drug 3) Polymorphism and Amorphism 4) Hydrates/Solvates (Pseudopolymorphism) 5) Salt form of the drug 6) Drug pKa and Lipophilicity and GI pHpH Partition Hypothesis 7) pKa of drug & gastrointestinal pH hypothesis 8) Drug stability PHYSICOCHEMICAL FACTORS AFFECTING DRUG ABSORPTION 1) Drug solubility & dissolution rate 2) Particle Size and Effective Surface Area of the Drug 3) Polymorphism and Amorphism 4) Hydrates/Solvates (Pseudopolymorphism) 5) Salt form of the drug 6) Drug pKa and Lipophilicity and GI pHpH Partition Hypothesis 7) pKa of drug & gastrointestinal pH hypothesis 8) Drug stability Consider the events that occur following oral administration of a solid dosage form as shown in Fig