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NSAID-associated gastropathy in distance runners and CrossFit athletes who reach for ibuprofen too readily, and IBD-adjacent symptoms in patients who are looking for adjuncts to standard care

Specifically, increased expression of AMPA receptors in hypoxic white matter sensitizes microglia to glutamate, leading to a regulatory response that reduces protective IGF-1 release, while increasing the release of inflammatory mediators (Sivakumar et al., 2010)

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Traumatic brain injury For decades, preclinical and small clinical studies have investigated the effect of citicoline when provided intravenously, intramuscularly, or orally in the management of traumatic brain injury (TBI)