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Indeed, in a recently completed Phase I trial of APR-246 in patients with haematological malignancies, it was noted that the addition of APR-246 to a patient receiving concurrent sorafenib resulted in complete remission of their acute myeloid leukaemia 35

Skin Discoloration or Hyperpigmentation : Long-term use of glutathione injections for skin lightening can result in unintended skin discoloration, uneven pigmentation, or hyperpigmentation

A caveat of targeted therapies, as exemplified by the development of tyrosine kinase inhibitors, is that they are useful only when their target(s) are the main drivers of carcinogenesis

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action