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doi: 10.1038/s41598-025-92868-y 74 PereiraAGEchaveJJorgeAOSNogueira-MarquesRNur YuksekEBarcielaPet al

Additionally, CAFs contribute to extracellular matrix remodeling, creating physical barriers to drug penetration and immune cell infiltration while altering mechanical signaling that influences metabolic pathways in cancer cells [49,50,51,52]