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Kool et al., 1997

In an aging brain, oxidative stress is a major contributing factor to chronic inflammation, leading to cognitive impairment, memory issues, or more serious manifestations

Additionally, microglia, the brains resident immune cells, exhibit a metabolic flexibility that allows them to shift between oxidative phosphorylation and glycolysis, depending on their activation state, which significantly influences neuroinflammation and synaptic plasticity

Isso pode incluir pessoas com dietas restritivas (e deficincias nutricionais que interfiram na produo da L-Carnitina pelo organismo) ou ainda portadores de doenas metablicas, por exemplo