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We also report the synthesis of an activity-based probe comprising ubiquitinated histone H2A and its incorporation into nucleosomes and demonstrate its reactivity with deubiquitinating enzyme to generate a covalent nucleosomeenzyme complex

They help regulate many biological processes, including hormone production, recovery, metabolism, tissue repair, muscle growth, and appetite regulation

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This mechanism may result in a reduction in ROS production via the Fenton reaction, eventually mitigating lipid peroxidation and mitochondrial damage, which provides valuable insights into the field