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Description

Proteasome inhibitors in multiple myeloma: 10 years later

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The reaction proceeds via the alpha-chloroamido derivative of the GSH-brostallicin adduct, is able to alkylate DNA in a sequence-specific manner and appears to be the active form of the drug, brostallicin cytotoxicity of brostallicin is higher in cells overexpressing either the GST-pi or the GST-mu gene Products: -

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10.1158/0008-5472.CAN-15-3199 65 LyuN.ZengY.KongY.ChenQ.DengH.OuS.et al (2021)

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Insights 18, 11779322241257039

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