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Of special interest in this context are lipid peroxidation products, in particular 4-hydroxynonenal (HNE), which has been shown to both induce DNA damage [96] but also to be involved in the regulation of cell proliferation and growth as well as necrotic or apoptotic cell death by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression (for review see [97])

Can mammalian reproductive health withstand massive exposure to polystyrene micro- and nanoplastic derivatives

In reality, oxidative stress may only be a secondary or downstream factor in many pathological processes