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Initial treatment for patients with neurological involvement follows British National Formulary (BNF) guidance: Hydroxocobalamin 1 mg intramuscularly on alternate days for approximately 2-3 weeks (or until no further improvement) Maintenance therapy then consists of hydroxocobalamin 1 mg intramuscularly every two months Hydroxocobalamin is preferred over cyanocobalamin in the UK due to superior retention and fewer injections required

DNA Synthesis: B12 is involved in the production of DNA, making it a crucial nutrient for cell division and growth

Add in the potential for GI side effects that deplete fluids, and dehydration becomes a real risk during retatrutide protocols

Obesity and obstructive respiratory disease with a chronic cough increase susceptibility