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This response is a key regulatory step in activating signal transduction pathways essential for defense mechanisms ( 2 O 2 and increased rates of lipid peroxidation (MDA), consistent with previous findings (Qureshi et al., 2007

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Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy