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Therefore, [Ca 2+ ] i variations are the primary response of many cell types to hypoxia and have a significant role in the modulation of signaling pathways and gene expression

Very frequent PVCs, estimated at 10,000 to 20,000 episodes a day, can weaken the heart muscle and increase the risk of heart failure if the condition isn't treated

Funding Open access funding provided by Manipal Academy of Higher Education, Manipal Ethics declarations Competing interests The authors declare no competing interests