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Long-term metabolic and oxidative imbalances, such as persistent ROS or mitochondrial decline, induce the expression of senescence-associated genes, including p16 and p21, and promote the secretion of SASP factors

(5.6) Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations

95% CI: 3.05, 13.1) and FIB-4 was strongly associated with hepatic encephalopathy (OR=5.50

Therefore, it was hypothesized that the degree of tumor sensitivity to THC is directly related to the degree of CB1R and CB2R expression and that THC may only kill tumors that express CBRs