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They secrete IL-1, basic fibroblast growth factor, and VEGF, and regulate Ca 2+ mobilization through CD38-mediated cADPR, which is conducive to TMM activation, angiogenesis, and immunosuppression ( The Role of Targeted CD38 (Therapy) in Diseases The Role of an Anti-CD38 Monoclonal Antibody (mAb)and Its Synergy in the Treatment of Multiple Myeloma Daratumumab is a human specific IgG1 anti-CD38 antibody, which has been approved as a single drug or combined regimen for the treatment of recurrent/refractory multiple myeloma

This may suggest the possible presence of additional or compensatory mechanisms of action