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4.2 Prebiotics as critical modulators of gut-thyroid homeostasis Prebiotics, indigestible dietary fibers that selectively stimulate the growth and activity of beneficial gut bacteria, serve as essential adjuncts to probiotic therapy and independently contribute to hypothyroidism management (Ouyang et al., 2024)

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Other studies have confirmed statin can activate NOS gene transcription, extend the half-life of NOS mRNA in skin cells and inhibit mevalonate- mediated isoprenoid synthesis to increase endothelial NOS activity [43] ( Figure 4 )