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It also influences cardiovascular homeostasis by activating the Ang II type 1 receptor, mainly found in cardiovascular cells [113]

Moreover, testosterone treatment led to an increase in intracellular Cer level within the KGN cells (Fig

Instead, it is mediated through the systemic administration of CB 1 agonists acting on peripheral CB 1 receptors, resulting in hypotension due to the inhibition of noradrenaline release from postganglionic sympathetic neurons ( locus coeruleus through the vagus nerve (see Figure 1)

Similar to caspase-mediated cell apoptosis (Wolf et al., 1999), the activation of calpain can also rupture cell lysosomes (Yap et al., 2006), resulting in the robust occurrence of secondary injury in the central nervous system after stroke