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Some of Jerne's thinking at that time is captured by his later close collaborator Ivan Lefkovits: 'Niels realized that Burnet's clonal selection was so clear, convincing and logical that there was little to add to it

The decision to continue or stop biologic agents should be individualised, taking into account alternative therapies, the severity of the mothers condition prior to therapy, the risk of disease flares caused by treatment cessation and the impact of a flare on the mother and the unborn child[1,116]

175 Recent advancements include the development of neuroprotective agents 114,176 with potentially profound implications for patient care

P., Jain, A., Tanwar, S., Yar, M