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Start: 2 mg weekly for 4 weeks to assess tolerance [6]

This process originates from the conversion of glutamine into glutamate through the catalysis of GLS, followed by the conversion of glutamate into -ketoglutarate (-KG) through catalysis by glutamine dehydrogenase (GDH) or transaminase (Fig

Key strategies include nationwide screening, active case finding, linkage to care, decentralized care, and provision of treatment for all persons with hepatitis C virus (HCV) infection, along with effective prevention interventions

7.1.3 mTOR inhibitors The mTOR inhibitors are the most extensively studied targeted therapies for the PI3K-AKT-mTOR signaling pathway and were the first to enter clinical practice (233)