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To address this gap, we established a human in vitro model of SORD deficiency by generating induced pluripotent stem cells (iPSCs) from fibroblasts affected individual carrying biallelic SORD mutations ( SORD c.757delG/c.316_425+165del ), and unaffected heterozygous carriers ( SORD c.757delG/wt and SORD wt/c.316_425+165del )

Protection from Conditioning the Cochlear Efferent System The outcomes of other experiments indicate that the mammalian cochlea may be capable of actively adapting to certain high-level sounds by receiving exposure experience. The notion that the cochlea can become resistant over time to the consequences of excessive sound was reported initially by noting conditioning effects in several animal models

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Those with heart conditions, high blood pressure, or certain mental health disorders may not be candidates for the medication