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Conflicts of interest C.M.L., D.M., and R.D

Similarly, PKA-RI/ subunits were identified as hub proteins followed by PKA-C/ in the ME15 (significant PS and MM), while the ME15 showed enrichment in macroautophagy, postsynaptic specialization, transport vesicle, and protein polymerization or depolymerization (Fig

The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007