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While Nrf2 is globally suppressed in COPD via promoter hypermethylation (138), its sustained but inadequate activation in macrophages drives ferritinophagy via NCOA4 (139)

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These results likely come from quercetin's ability to block multiple enzymes in purine metabolism

By suppressing UVB-induced MMP expression and boosting procollagen I synthesis, trehalose mitigates the detrimental photoaging effects of UV radiation