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Factor in the rapid clearance mechanism, whereby nasally-applied drugs are cleared with a half-life of approximately 21 minutes, and its clear why only certain peptides can be used nasally

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Second, as mentioned above, c-Met inhibitors which target the interaction between HGF and c-Met may lose efficacy owing to cell attachment (Wang et al., 2001), gene amplification of c-Met, DCP binding to c-Met (Suzuki et al., 2005), gene mutation in the c-Met activation loop (Okuma and Kondo, 2016) and crosstalk with other membrane receptors (Garcia-Vilas and Medina, 2018)

Binding of a 4-Methyl-4-Aza-Steroid to 5-Reductase of Rat Liver and Prostate Microsomes.Endocrinology1983,112, 1460-1468 80